2,8-Dibromoquinoline(CAS: 871507-79-8)

2,8-Dibromoquinoline is a crystalline solid with a molecular weight of approximately 310.05 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophilic substitutions. It is often used as a precursor in organic synthesis due to its bromine substituents.

2,8-Dibromoquinoline is typically synthesized via a nucleophilic aromatic substitution reaction, where bromine substitutes at the quinoline ring. Common methods include the use of bromine in the presence of a Lewis acid catalyst like aluminum bromide, providing good yield and selectivity. The reaction is exothermic and should be carefully controlled.

2,8-Dibromoquinoline is primarily used in pharmaceuticals for synthesizing key intermediates and in polymer science for developing novel materials with specific properties. It also finds applications in sensor technology and semiconductor industries due to its unique electronic and structural properties.

When handling 2,8-Dibromoquinoline, it is crucial to wear appropriate personal protective equipment (PPE) including safety goggles, gloves, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbents and waste should be disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.