5-Bromo-4(3H)-pyrimidinone(CAS: 19808-30-1)

5-Bromo-4(3H)-pyrimidinone is a crystalline solid with a molecular weight of 235.03 g/mol. It is slightly soluble in water and ethanol. The compound exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It is stable under normal storage conditions but should be protected from moisture and light.

5-Bromo-4(3H)-pyrimidinone is synthesized via bromination of 4(3H)-pyrimidinone. Common methods include the use of N-bromosuccinimide (NBS) in the presence of a radical initiator. The reaction is typically carried out in dichloromethane (DCM) or other suitable organic solvents, providing high selectivity and yield.

5-Bromo-4(3H)-pyrimidinone is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the polymer industry for the development of functional polymers, in the semiconductor industry for photoresists, and in the sensor industry for the fabrication of gas sensors.

When handling 5-Bromo-4(3H)-pyrimidinone, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.