1-(4-Nitrophenyl)-1H-imidazole(CAS: 2301-25-9)

1-(4-Nitrophenyl)-1H-imidazole (CAS: 2301-25-9) is a crystalline solid with a molecular weight of approximately 204.14 g/mol. It is slightly soluble in water and ethanol. Chemically, it is less reactive compared to other imidazoles but shows good reactivity towards nucleophiles. It is stable under normal conditions but is prone to hydrolysis in basic media.

1-(4-Nitrophenyl)-1H-imidazole can be synthesized via the condensation of 4-nitrophenyl isocyanate with 1H-imidazole. This reaction typically requires a coupling agent or a base catalyst. The yield is usually around 75-85%, and the product is purified by recrystallization from ethanol.

1-(4-Nitrophenyl)-1H-imidazole (CAS: 2301-25-9) is used in various industries, including pharmaceuticals for synthesis of certain drugs, sensors for detecting specific chemicals, and as a precursor in polymer synthesis. It also has applications in the semiconductor industry for certain thin-film processes.

When handling 1-(4-Nitrophenyl)-1H-imidazole (CAS: 2301-25-9), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, immediately contain it, clean up with appropriate absorbents, and dispose of the waste according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.