4-Aminobenzo-12-crown-4(CAS: 78554-68-4)

4-Aminobenzo-12-crown-4 (CAS: 78554-68-4) is a yellow or orange crystalline solid with a molecular weight of approximately 252.25 g/mol. It has a low solubility in water but is highly soluble in organic solvents such as methanol and ethanol. The compound is known for its stability and non-reactivity under normal conditions, but it can undergo hydrolysis in the presence of strong acids or bases.

4-Aminobenzo-12-crown-4 is commonly synthesized by the condensation of 4-aminobenzoic acid with 1,4-cyclohexanedione. This reaction typically requires aprotic solvents like acetonitrile and is often catalyzed by a mild base such as triethylamine. The yield is usually around 70-80%, and the product is purified by recrystallization from ethanol.

4-Aminobenzo-12-crown-4 (CAS: 78554-68-4) is used in the pharmaceutical industry for its ability to form stable complexes with metal ions, which is beneficial in drug design and delivery. It is also utilized in the semiconductor industry for its potential in sensor applications due to its coordination chemistry. Additionally, it has applications in polymer chemistry and as a ligand in catalysis.

When handling 4-Aminobenzo-12-crown-4 (CAS: 78554-68-4), it is important to wear appropriate personal protective equipment (PPE) such as gloves and eye protection. The compound should be handled in a well-ventilated area or within a fume hood to minimize inhalation risks. Spills should be immediately cleaned up using appropriate disposal methods. For detailed safety information, refer to the safety data sheet (SDS).