Compound Q&A
How is 4-Aminobenzo-12-crown-4 (CAS: 78554-68-4) typically synthesized?
Answer
4-Aminobenzo-12-crown-4 is commonly synthesized by the condensation of 4-aminobenzoic acid with 1,4-cyclohexanedione. This reaction typically requires aprotic solvents like acetonitrile and is often catalyzed by a mild base such as triethylamine. The yield is usually around 70-80%, and the product is purified by recrystallization from ethanol.
About
CAS No
78554-68-4
English Name
4-Aminobenzo-12-crown-4
Molecular Formula
C12H17NO4
Molecular Weight
239.27 g/mol
SMILES
C1COCCOC2=C(C=CC(=C2)N)OCCO1
InChIKey
ZKICIJKRTPWQSI-UHFFFAOYSA-N
Last Updated: 2026-01-07 14:58
