1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide(CAS: 701-44-0)

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide, also known as 6-oxo-1,6-dihydropyrido[3,2-b]pyridine-3-carboxamide, is a white crystalline solid (CAS: 701-44-0). Its molecular weight is approximately 229.24 g/mol. It is soluble in organic solvents such as methanol and dimethylformamide. This compound is relatively stable but can react with strong bases to form the corresponding amine. It is also known for its amphoteric nature.

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide can be synthesized through a multi-step process involving the condensation of methyl acrylate and 2-pyridone, followed by oxidation. The reaction typically requires a catalyst such as concentrated sulfuric acid. The overall yield is moderate, and the product can be purified by crystallization from an appropriate solvent. This method allows for good selectivity and yields.

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS: 701-44-0) finds applications in pharmaceuticals, where it serves as a precursor for drug development. It is also utilized in the production of polymers and as a component in sensors and semiconductors. Its structural properties make it suitable for various industrial applications.

When handling 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS: 701-44-0), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using an appropriate neutralizing agent and disposed of according to local regulations. It is recommended to consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.