2'-Cytidylic acid(CAS: 85-94-9)

2'-Cytidylic acid is a white crystalline solid with a molecular weight of approximately 346.21 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive towards base catalyzed hydrolysis and is stable under acidic conditions. It has a pKa of approximately 7.0.

2'-Cytidylic acid is commonly synthesized through the condensation of cytosine and ATP in the presence of a base catalyst such as sodium carbonate. The reaction is typically performed in aqueous media at neutral pH. Yields are usually around 70-80%, and the product can be purified by column chromatography or recrystallization.

2'-Cytidylic acid is primarily used in the pharmaceutical industry for the synthesis of nucleoside analogs and antiviral drugs. It also finds applications in the polymer industry for the development of biodegradable polymers and in the semiconductor industry as a dopant in organic thin-film transistors.

When handling 2'-Cytidylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood due to its potential to generate reactive metabolites. Spills should be cleaned up with caution, using absorbent materials and disposing of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.