Ciluprevir(CAS: 300832-84-2)

Ciluprevir is a white or off-white crystalline powder with a molecular weight of approximately 485.47 g/mol. It has a solubility of about 20 mg/mL in water and is practically insoluble in organic solvents. Chemically, it is stable under normal conditions but can degrade under acidic or basic conditions. It exhibits good reactivity towards nucleophilic substitution reactions.

Ciluprevir is synthesized via a multi-step process involving Friedel-Crafts alkylation and subsequent ring-closing metathesis reactions. The key catalysts used include ruthenium-based metathesis catalysts and anhydrous conditions to ensure high yield and selectivity. The overall process yields approximately 85% of the desired product with minimal side products.

Ciluprevir is primarily used in the pharmaceutical industry. It is an antiviral drug used in the treatment of hepatitis C. While it has applications in other fields, its main use is in the production of medications for viral infections. Ciluprevir is not widely used in industries such as polymers, sensors, or semiconductors.

When handling Ciluprevir, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions. Storage should be at room temperature away from direct sunlight and moisture.