N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3,4,5,6-pentafluoro-D-phenylalanine(CAS: 198545-85-6)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3,4,5,6-pentafluoro-D-phenylalanine (CAS: 198545-85-6) is a crystalline compound with a molecular weight of approximately 548.26 g/mol. It is poorly soluble in water but soluble in organic solvents like dichloromethane and acetonitrile. The compound is stable under normal conditions but reacts with strong bases. It is an important building block in medicinal chemistry due to its unique functional groups.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3,4,5,6-pentafluoro-D-phenylalanine (CAS: 198545-85-6) is synthesized through a multistep process involving fluorenylmethanol, D-phenylalanine, and a coupling reagent. The synthesis involves the formation of the fluorenylmethoxycarbonyl (Fmoc) ester derivative and subsequent amidation. Common catalysts include HATU or EDC. Yields and selectivity are generally high, making it a valuable intermediate in pharmaceutical research.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3,4,5,6-pentafluoro-D-phenylalanine (CAS: 198545-85-6) is primarily used in the pharmaceutical industry for the synthesis of complex molecules. It is also utilized in the development of sensors and polymers due to its unique functional groups and stability. Its applications in semiconductor technology are limited but remain an area of ongoing research.

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3,4,5,6-pentafluoro-D-phenylalanine (CAS: 198545-85-6), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbents, and the area should be ventilated. Refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.