2-(4-Piperidinyloxy)pyrimidine(CAS: 499240-48-1)

2-(4-Piperidinyloxy)pyrimidine (CAS: 499240-48-1) is a white crystalline solid with a molecular weight of approximately 242.4 g/mol. It has a solubility of about 2.3 mg/mL in water and is sparingly soluble in organic solvents such as ethanol. The compound is known for its chemical stability but can react with acids to form pyrimidine-2-carboxylic acid. It is non-flammable and has a pKa of 8.8.

2-(4-Piperidinyloxy)pyrimidine can be synthesized through a multi-step process involving the reaction of 4-hydroxypiperidine with 2-bromopyrimidine in the presence of a base such as potassium carbonate. The reaction is typically performed in an aprotic solvent like dimethylformamide (DMF) at elevated temperatures. The product is isolated by crystallization from a suitable solvent, and the purity is confirmed by spectroscopic techniques.

2-(4-Piperidinyloxy)pyrimidine (CAS: 499240-48-1) is primarily used in the pharmaceutical industry, particularly in the development of new drugs. It is also utilized in the polymer industry for the synthesis of functional polymers and in the sensor industry for developing biosensors. Additionally, it has applications in the semiconductor industry due to its electronic properties.

When handling 2-(4-Piperidinyloxy)pyrimidine (CAS: 499240-48-1), it is important to wear protective gloves and goggles to prevent skin contact and eye exposure. Use a fume hood during handling and preparation to minimize inhalation risk. Spills should be cleaned up using appropriate absorbent materials and disposed of in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.