Imidazo[1,5-a]pyridine-7-carboxylic acid(CAS: 588720-29-0)

Imidazo[1,5-a]pyridine-7-carboxylic acid is a crystalline solid with a molecular weight of approximately 239.24 g/mol. It is slightly soluble in water and solvents like ethanol and methanol. The compound is chemically reactive, particularly towards nucleophilic substitution and condensation reactions.

Imidazo[1,5-a]pyridine-7-carboxylic acid can be synthesized via the condensation of 2-acetylpyridine with 1H-imidazole followed by the removal of the acetyl group. The reaction typically uses thionyl chloride for acetylation and a catalytic amount of pyridine for deacetylation.

Imidazo[1,5-a]pyridine-7-carboxylic acid finds applications in pharmaceuticals, where it serves as a precursor for drug synthesis, and in the development of advanced polymers and sensors. It also has potential uses in the semiconductor industry for doping purposes.

Handling Imidazo[1,5-a]pyridine-7-carboxylic acid requires caution as it is a reactive compound. Always wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a well-ventilated fume hood or a well-ventilated area. Follow standard laboratory safety protocols and consult the Safety Data Sheet (SDS) for specific handling instructions.