2-Chloro-6-nitrobenzaldehyde(CAS: 6361-22-4)

2-Chloro-6-nitrobenzaldehyde is a crystalline solid with a molecular weight of approximately 228.04 g/mol. Its solubility in water is low, with a solubility of about 0.1 g/L at 25°C. Reactivity is moderate, showing typical reactivity of benzaldehydes, including electrophilic aromatic substitution and nucleophilic addition reactions. It is highly reactive towards reducing agents and can undergo hydrolysis under basic conditions.

2-Chloro-6-nitrobenzaldehyde is commonly synthesized via nitration of 2-chlorobenzaldehyde followed by reduction of the nitro group. Alternatively, it can be prepared by chlorination of 6-nitrobenzaldehyde. The synthesis typically involves the use of concentrated nitric and sulfuric acids as reagents, with careful temperature control to ensure selectivity and yield.

2-Chloro-6-nitrobenzaldehyde finds applications in pharmaceuticals, where it serves as a precursor for the synthesis of various organic compounds and drugs. It is also used in the production of dyes and pigments, as well as in the development of sensors and semiconductors. The compound's unique chemical properties make it valuable in these industries for its reactivity and potential in organic synthesis.

When handling 2-Chloro-6-nitrobenzaldehyde, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate safety protocols. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.