4-(3-Fluorobenzyl)piperidine(CAS: 202126-85-0)

4-(3-Fluorobenzyl)piperidine is a colorless to light yellow liquid at room temperature. It has a molecular weight of approximately 228.21 g/mol. The compound is slightly soluble in water but miscible with most organic solvents. It is moderately reactive, showing basic behavior due to the piperidine ring, and can undergo nucleophilic substitution reactions.

4-(3-Fluorobenzyl)piperidine is typically synthesized by the reaction of 3-fluorobenzyl bromide with piperidine in the presence of a base such as potassium carbonate. The reaction is conducted in an aprotic solvent like dimethylformamide (DMF). The yield is usually around 75-85%, and the reaction is carried out at room temperature with high selectivity.

4-(3-Fluorobenzyl)piperidine is used in the pharmaceutical industry for the synthesis of various drug candidates due to its structural similarity to other biologically active compounds. It is also used in the polymer industry for modifying the properties of polymers and in the sensor industry for developing gas sensors.

When handling 4-(3-Fluorobenzyl)piperidine, it is important to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. The compound should be stored in a cool, dry place, away from heat and sources of ignition. In case of a spill, use appropriate spill cleanup materials and follow the safety data sheet (SDS) for further instructions.