4-Amino-1,3-dihydro-2H-benzimidazol-2-one(CAS: 75370-65-9)

4-Amino-1,3-dihydro-2H-benzimidazol-2-one is a crystalline solid with a molecular weight of approximately 170.21 g/mol. It is slightly soluble in water and ethanol. Chemically, it is known for its reactivity in nucleophilic substitution reactions and can form stable complexes with metal ions. Its pKa value is around 10.5, indicating basicity.

4-Amino-1,3-dihydro-2H-benzimidazol-2-one can be synthesized via the Friedel-Crafts alkylation of 2-benzimidazolone or by the condensation of 2-benzimidazolinone with ammonia. The reactions are typically catalyzed by Lewis acids such as aluminum trichloride. The yield is generally around 70-80%, with high selectivity for the desired product.

4-Amino-1,3-dihydro-2H-benzimidazol-2-one is widely used in the pharmaceutical industry as a precursor for drug synthesis, specifically in the development of antiviral and anticancer drugs. It also finds applications in the production of some dyes and pigments. Additionally, it is utilized in the synthesis of certain polymers and sensors.

When handling 4-Amino-1,3-dihydro-2H-benzimidazol-2-one, wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store it in a cool, dry place away from direct sunlight and flammable materials. Use a fume hood during synthesis and handling to avoid inhalation. In case of spill, clean up using appropriate absorbents and follow standard laboratory safety procedures. Refer to the Material Safety Data Sheet (MSDS) for more detailed information.