2-Amino-6-hydroxy-5-nitro-4(1H)-pyrimidinone(CAS: 80466-56-4)

2-Amino-6-hydroxy-5-nitro-4(1H)-pyrimidinone is a crystalline solid with a molecular weight of approximately 236.09 g/mol. It has a solubility of about 0.1 g/100 mL in water at 25°C and exhibits moderate reactivity towards bases and reducing agents. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

2-Amino-6-hydroxy-5-nitro-4(1H)-pyrimidinone can be synthesized through the nitration of 2-hydroxy-5-nitropyrimidine followed by reduction of the nitro group to an amino group. Commonly used conditions include the use of nitric acid in the presence of sulfuric acid as a catalyst, and subsequent hydrogenation to achieve the desired amino functionality.

2-Amino-6-hydroxy-5-nitro-4(1H)-pyrimidinone finds applications in the pharmaceutical industry as a precursor for the synthesis of various medicinal compounds. It also has potential uses in the polymer industry for the development of functional polymers and in the sensor and semiconductor industries for material characterization and device fabrication.

When handling 2-Amino-6-hydroxy-5-nitro-4(1H)-pyrimidinone, it is essential to wear protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with care, using appropriate absorbents, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed safety guidelines.