Methyl 6-aminonicotinate(CAS: 36052-24-1)

Methyl 6-aminonicotinate (CAS: 36052-24-1) is a white crystalline solid with a molecular weight of approximately 191.21 g/mol. It is slightly soluble in water and ethanol. Chemically, it exhibits basic properties due to the presence of the amine group. It is moderately reactive and can undergo various chemical transformations, such as esterification and substitution reactions.

Methyl 6-aminonicotinate is typically synthesized by the reaction of methyl 6-chloronicotinate with sodium hydride, followed by the addition of an amine. This process involves the displacement of the chloride group with an amine, yielding the desired product with high selectivity and good yield. The reaction is usually carried out in an inert solvent like dimethylformamide (DMF).

Methyl 6-aminonicotinate (CAS: 36052-24-1) finds applications in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the sensor industry due to its ability to act as a chromogenic reagent for detecting certain metal ions. Additionally, it can be utilized in the semiconductor industry for thin film applications.

When handling Methyl 6-aminonicotinate (CAS: 36052-24-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Proper spill cleanup procedures should be followed, and storage should be in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.