2,1,3-Benzothiadiazole-4-sulfonyl chloride(CAS: 73713-79-8)

2,1,3-Benzothiadiazole-4-sulfonyl chloride is a crystalline compound with a molecular weight of approximately 223.21 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is known for its reactivity, particularly in nucleophilic substitution reactions. It is a strong electrophile due to the presence of the sulfonyl chloride group.

2,1,3-Benzothiadiazole-4-sulfonyl chloride is synthesized by the reaction of 2,1,3-benzothiadiazole with thionyl chloride. This reaction typically requires heating and proceeds with good yield and selectivity. The use of anhydrous conditions ensures the stability and efficacy of the reaction.

2,1,3-Benzothiadiazole-4-sulfonyl chloride finds applications in pharmaceuticals for its potential as an intermediate in drug synthesis, as well as in the polymer industry for the modification of polymer properties. It is also used in the development of sensors and semiconductors due to its unique chemical properties and reactivity.

Proper handling of 2,1,3-Benzothiadiazole-4-sulfonyl chloride requires the use of personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. The compound should be handled in a fume hood to minimize exposure. Spills should be cleaned up carefully, using appropriate absorbent materials, and the area should be well-ventilated. It is recommended to consult the Safety Data Sheet (SDS) for detailed safety information.