6-bromo-4-fluoro-1H-indole(CAS: 885520-59-2)

6-Bromo-4-fluoro-1H-indole (CAS: 885520-59-2) is a crystalline solid with a molecular weight of approximately 234.03 g/mol. This compound has a low water solubility (less than 1 g/L), making it poorly soluble in water. It is moderately soluble in common organic solvents like ethanol and acetonitrile. The compound is known for its moderate reactivity, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

6-Bromo-4-fluoro-1H-indole (CAS: 885520-59-2) can be synthesized through a multistep process involving the bromination of 4-fluoro-1H-indole followed by further functional group modifications. Common synthetic methods include the use of N-bromosuccinimide (NBS) for bromination under UV light, with selectivity towards the indole ring. The overall yield of the final product is generally around 70-80%, depending on the purity of starting materials and reaction conditions.

6-Bromo-4-fluoro-1H-indole (CAS: 885520-59-2) finds applications in various industries, particularly in pharmaceuticals where it serves as an intermediate for synthesizing drug candidates. It is also used in the development of materials for sensors and semiconductors due to its unique electronic properties. Its chemical reactivity makes it suitable for use in polymer synthesis, contributing to the development of advanced materials with specific functionalities.

When handling 6-bromo-4-fluoro-1H-indole (CAS: 885520-59-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The substance should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be handled with care, using appropriate absorbent materials, and the area should be ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures. This compound should not be inhaled and should not come into contact with skin or eyes.