(1S,3aR,6aS)-tert-Butyl octahydrocyclopenta[c]pyrrole-1-carboxylate oxalate(CAS: 907606-68-2)

(1S,3aR,6aS)-tert-Butyl octahydrocyclopenta[c]pyrrole-1-carboxylate oxalate is a white crystalline solid with a molecular weight of approximately 312.44 g/mol. It has a moderate solubility in organic solvents like methanol and ethanol, but is sparingly soluble in water. It exhibits good stability under normal conditions but is susceptible to hydrolysis in aqueous solutions. It is typically used in organic synthesis as a building block for various functionalized compounds.

(1S,3aR,6aS)-tert-Butyl octahydrocyclopenta[c]pyrrole-1-carboxylate oxalate is synthesized via a multi-step process. The key steps include the synthesis of the oxime from the corresponding carboxylic acid, followed by an intramolecular cyclization and oxalate esterification. Common solvents include dichloromethane and acetonitrile, with triethylamine as a base. The overall yield is around 70-80%, with good regioselectivity and stereoselectivity.

(1S,3aR,6aS)-tert-Butyl octahydrocyclopenta[c]pyrrole-1-carboxylate oxalate finds applications in the pharmaceutical industry as an intermediate in the synthesis of complex organic molecules. It is also used in polymer chemistry, where it serves as a monomer or building block. Its use in sensor technology and semiconductor devices is also being explored, though less extensively than in pharmaceutical and polymer industries.

When handling (1S,3aR,6aS)-tert-Butyl octahydrocyclopenta[c]pyrrole-1-carboxylate oxalate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up carefully, using appropriate absorbents, and the area should be rinsed thoroughly. Refer to the safety data sheet (SDS) for detailed handling and disposal instructions. Storage should be in a cool, dry place, away from direct sunlight and heat sources.