2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde(CAS: 29668-43-7)

2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde is a colorless to light yellow crystalline solid with a molecular weight of approximately 184.21 g/mol. It has a solubility of about 0.25 g/L in water and is soluble in organic solvents like methanol and ethanol. This compound is reactive, showing basic and electrophilic character, making it useful in various chemical transformations and reactions.

2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde can be synthesized by the condensation of 2,3-dihydro-1,4-benzodioxin-5-one with formaldehyde in the presence of a strong base such as sodium hydroxide. The reaction is typically carried out in a polar aprotic solvent like dimethylformamide (DMF) at elevated temperature. The yield is generally around 70-80%.

2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde is used in the pharmaceutical industry for the synthesis of bioactive compounds, in the polymer industry for the modification of polymer properties, and in the sensor industry for developing gas sensors. It is also utilized in the semiconductor industry for the production of certain organic semiconductors.

When handling 2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde, it is important to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The reaction mixture should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and the site should be rinsed with water. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.