12-Epinapelline(CAS: 110064-71-6)

12-Epinapelline is a crystalline compound with a molecular weight of approximately 377.44 g/mol. It has a solubility of about 1 mg/mL in water and is slightly soluble in methanol. Chemically, it is reactive towards acid and base conditions, making it susceptible to hydrolysis.

12-Epinapelline can be synthesized via a multi-step process involving ring-opening of a lactone, followed by reduction and protection of functional groups. Commonly, this involves using lithium aluminum hydride (LAH) as a reducing agent and acetic anhydride for acylation. The overall yield is around 70% to 80%.

12-Epinapelline is primarily used in the pharmaceutical industry for the development of new anti-inflammatory drugs. It is also explored in the sensor industry for its potential as a gas sensing material due to its reactivity with certain gases.

Handling 12-Epinapelline requires the use of personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood due to its reactivity. Spills should be cleaned up using absorbent material and disposed of according to local regulations. The Safety Data Sheet (SDS) should be consulted for detailed information.