1-(2,4-Dichloro-5-pyrimidinyl)ethanone(CAS: 871254-62-5)

1-(2,4-Dichloro-5-pyrimidinyl)ethanone is a crystalline solid with a molecular weight of approximately 272.06 g/mol. It is sparingly soluble in water but highly soluble in organic solvents such as ethanol and acetone. Chemically, it is reactive and can undergo nucleophilic substitution reactions. It is typically stable under normal conditions but should be stored in a cool, dry place away from moisture and heat.

1-(2,4-Dichloro-5-pyrimidinyl)ethanone is commonly synthesized via the condensation of 2,4-dichloropyrimidine with acetaldehyde in the presence of a base such as sodium hydroxide. The reaction is typically conducted in an organic solvent like ethanol. The yield is around 80%, and the method is known for its good selectivity and mild conditions.

1-(2,4-Dichloro-5-pyrimidinyl)ethanone is used in the pharmaceutical industry for the synthesis of certain drugs and in the polymer industry for creating functionalized polymers. It also finds applications in the development of sensors and semiconductors due to its unique chemical structure and reactivity.

When handling 1-(2,4-Dichloro-5-pyrimidinyl)ethanone, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood due to its reactivity. In case of a spill, immediately clean up in a well-ventilated area and ensure proper disposal. Always consult the material safety data sheet (MSDS) for detailed safety information.