7-Bromofuro[3,2-c]pyridine(CAS: 603300-96-5)

7-Bromofuro[3,2-c]pyridine is a crystalline solid with a molecular weight of approximately 229.03 g/mol. It is slightly soluble in common organic solvents such as dichloromethane and acetonitrile. The compound is moderately reactive, particularly towards nucleophilic substitution reactions at the bromine atom. Its solubility in water is minimal, making it suitable for various synthetic and analytical applications.

7-Bromofuro[3,2-c]pyridine is typically synthesized via a classic vinylogous Friedel-Crafts acylation of 1,3-dibromopyridine with furan, followed by ring closure. This method allows for the selective introduction of the bromine atom at the desired position. The reaction involves the use of a Lewis acid catalyst, such as aluminum chloride, to facilitate the electrophilic aromatic substitution. The overall yield is around 80%, depending on the purity of the starting materials and reaction conditions.

7-Bromofuro[3,2-c]pyridine is used in various industries, particularly in pharmaceuticals for the synthesis of complex heterocyclic compounds and as an intermediate in the development of new drugs. It is also utilized in polymer chemistry for the modification of polymer properties and in the production of sensors and semiconductors due to its unique electronic properties.

Proper handling of 7-Bromofuro[3,2-c]pyridine requires the use of personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. In the event of a spill, it is important to clean it up with appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.