How is 7-Bromofuro[3,2-c]pyridine (CAS: 603300-96-5) typically synthesized?

7-Bromofuro[3,2-c]pyridine is typically synthesized via a classic vinylogous Friedel-Crafts acylation of 1,3-dibromopyridine with furan, followed by ring closure. This method allows for the selective introduction of the bromine atom at the desired position. The reaction involves the use of a Lewis acid catalyst, such as aluminum chloride, to facilitate the electrophilic aromatic substitution. The overall yield is around 80%, depending on the purity of the starting materials and reaction conditions.