6-Bromo-3-quinolinecarboxylic acid(CAS: 798545-30-9)

6-Bromo-3-quinolinecarboxylic acid is a crystalline solid with a molecular weight of approximately 240.04 g/mol. It has a pKa of around 1.6 and is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It exhibits good reactivity towards nucleophiles and can be used in various synthesis reactions.

6-Bromo-3-quinolinecarboxylic acid is commonly synthesized via bromination of 3-quinolinecarboxylic acid using N-bromosuccinimide (NBS) in anhydrous conditions. The reaction is usually carried out under light or UV irradiation, and the product can be isolated by recrystallization from a suitable solvent.

6-Bromo-3-quinolinecarboxylic acid is used in the pharmaceutical and chemical industries for the synthesis of various drugs and intermediates. It also finds applications in the production of dyes, pigments, and as a precursor in the development of new materials such as polymers and sensors.

When handling 6-Bromo-3-quinolinecarboxylic acid, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work must be carried out in a fume hood to minimize inhalation of fumes. Spills should be cleaned up using appropriate methods, and the substance should be stored in a cool, dry place away from moisture and heat sources. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.