Methyl (2-aminophenyl)acetate(CAS: 35613-44-6)

Methyl (2-aminophenyl)acetate (CAS: 35613-44-6) is a colorless or light yellow crystalline solid with a molecular weight of approximately 186.24 g/mol. It has a solubility of about 5.2 g/100 mL in water and is slightly soluble in ethanol. The compound is reactive towards nucleophiles, particularly amines and phenols, and can undergo condensation reactions. It has a melting point of around 60-62°C and a boiling point of approximately 160-165°C.

Methyl (2-aminophenyl)acetate (CAS: 35613-44-6) is synthesized via a condensation reaction between 2-aminophenol and acetic anhydride. The reaction proceeds under mild conditions in the presence of a catalytic amount of a Lewis acid, such as aluminum chloride, to selectively form the desired ester. The yield is typically around 70-80%, and the product can be purified by recrystallization from a suitable solvent.

Methyl (2-aminophenyl)acetate (CAS: 35613-44-6) is primarily used in the pharmaceutical, polymer, and sensor industries. It serves as a precursor in the synthesis of various pharmaceuticals, enhances the properties of polymers, and acts as a sensing component in gas detection systems. Additionally, it can contribute to the development of semiconductor materials.

When handling Methyl (2-aminophenyl)acetate (CAS: 35613-44-6), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using a suitable absorbent material and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.