[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile(CAS: 396131-82-1)

[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile is a crystalline compound with a molecular weight of approximately 326.37 g/mol. It has a low solubility in water but is soluble in organic solvents. This compound is known for its reactivity in organoboron chemistry, particularly in Suzuki couplings. It is stable under normal conditions but should be kept away from strong oxidizers and heat.

[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile is typically synthesized through a multistep process. The key step involves the reaction of phenylacetonitrile with 1,3,2-dioxaborine in the presence of a palladium catalyst and a base. The yield is generally around 70-80%, with good selectivity. This synthesis is commonly used in organoboron chemistry.

[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of organic compounds, particularly in the development of new drugs and the preparation of materials with specific properties. Its use in semiconductors and sensors is also growing due to its reactivity in organoboron chemistry.

Proper handling of [3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile (CAS: 396131-82-1) requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from heat and strong oxidizers. In case of a spill, it should be handled with appropriate spill kits and proper disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.