5-Nitro-2(1H)-pyrimidinone(CAS: 3264-10-6)

5-Nitro-2(1H)-pyrimidinone is a crystalline solid with a molecular weight of approximately 161.06 g/mol. It has a high solubility in polar solvents like water and ethanol. Chemically, it is moderately reactive, showing good stability but susceptible to hydrolysis under basic conditions. It is an important intermediate in the synthesis of various bioactive compounds.

5-Nitro-2(1H)-pyrimidinone can be synthesized via nitration of 2(1H)-pyrimidinone. Commonly, this involves treating pyrimidinone with nitric acid in the presence of an acid catalyst such as sulfuric acid. The reaction is carried out at room temperature, and yields up to 85% are achievable. High selectivity is maintained under these conditions.

5-Nitro-2(1H)-pyrimidinone is primarily used in the pharmaceutical industry for the synthesis of drug intermediates and as a reagent in organic chemistry. It also finds applications in the polymer industry for modifying polymer properties and in sensor technology for its reactivity to certain analytes.

Proper handling of 5-Nitro-2(1H)-pyrimidinone requires the use of personal protective equipment (PPE) including gloves, goggles, and lab coats. Store it in a cool, dry place away from heat sources. Fume hoods should be used during handling to minimize exposure. In the case of spills, immediately clean up with appropriate absorbents and follow safety data sheet (SDS) guidelines for disposal.