3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride(CAS: 4462-55-9)

The compound is a white or off-white crystalline solid with a molecular weight of approximately 311.04 g/mol. It has a low solubility in water but good solubility in organic solvents such as ethanol and acetone. Chemically, it is highly reactive, particularly towards nucleophiles and bases. It can form stable adducts and derivatives under mild conditions.

The compound is usually synthesized by chlorination of 5-methyl-1,2-oxazole-4-carbonyl chloride followed by coupling with 2,6-dichlorophenyl chloride. The reaction is typically conducted under anhydrous conditions using a Lewis acid catalyst to promote electrophilic aromatic substitution reactions.

This compound is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the manufacture of organic semiconductors and polymers due to its electronic properties. Additionally, it can be employed in the development of chemical sensors and as a reagent in analytical chemistry.

Handling this compound requires strict laboratory safety protocols. It should always be conducted in a well-ventilated area, preferably under a fume hood. Use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Spills should be cleaned up immediately using the appropriate absorbent material and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information.