6-Chloro-3-phenyl[1,2,4]triazolo[4,3-b]pyridazine(CAS: 7190-80-9)

6-Chloro-3-phenyl[1,2,4]triazolo[4,3-b]pyridazine is a crystalline solid with a molecular weight of approximately 277.71 g/mol. It has a high solubility in organic solvents like DMF and poor solubility in water. The compound is less reactive compared to other chlorinated aromatic compounds, showing moderate reactivity in electrophilic aromatic substitution reactions.

6-Chloro-3-phenyl[1,2,4]triazolo[4,3-b]pyridazine can be synthesized through the condensation of 3-phenyl-1,2,4-triazol-5(4H)-one with chloroacetyl chloride, followed by amination. The synthesis typically involves the use of a base such as triethylamine and proceeds with good yield and selectivity.

6-Chloro-3-phenyl[1,2,4]triazolo[4,3-b]pyridazine is primarily used in the pharmaceutical industry for the development of new drugs. It also finds applications in organic electronics, particularly in the fabrication of organic semiconductors for thin-film transistors and organic light-emitting diodes.

When handling 6-Chloro-3-phenyl[1,2,4]triazolo[4,3-b]pyridazine, proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn. This compound should be used in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be cleaned up immediately, and the area should be flushed with water. Always refer to the SDS for detailed safety information and follow all safety guidelines.