6-Bromo-1,3-benzoxazol-2-amine(CAS: 52112-66-0)

6-Bromo-1,3-benzoxazol-2-amine is a crystalline solid with a molecular weight of approximately 220.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and chloroform. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It can undergo substitution reactions, and its bromine functionality can participate in electrophilic aromatic substitution reactions.

6-Bromo-1,3-benzoxazol-2-amine is typically synthesized through the bromination of 1,3-benzoxazol-2-one followed by an aminolysis reaction. The bromination step often uses N-bromosuccinimide (NBS) in an organic solvent like dichloromethane. The aminolysis step involves treating the brominated product with an amine in a suitable solvent, such as ethanol or dimethylformamide (DMF).

6-Bromo-1,3-benzoxazol-2-amine finds applications in the pharmaceutical industry for the development of certain drug candidates. It is also utilized in the polymer industry for the synthesis of functionalized polymers. Additionally, it is used in the sensor technology sector for the preparation of specific chemical sensors. Its potential use in semiconductor manufacturing processes is also under investigation.

When handling 6-Bromo-1,3-benzoxazol-2-amine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to the compound. In case of a spill, it should be immediately cleaned up using the appropriate absorbent material and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.