Diethyl [(2-chloroethoxy)methyl]phosphonate(CAS: 116384-56-6)

Diethyl [(2-chloroethoxy)methyl]phosphonate (CAS: 116384-56-6) is a colorless to slightly yellow liquid with a molecular weight of approximately 269.04 g/mol. It has a solubility of about 0.5 g/100 mL in water and is soluble in organic solvents. The compound is reactive, particularly towards nucleophiles and bases, and it can undergo hydrolysis under basic conditions.

Diethyl [(2-chloroethoxy)methyl]phosphonate (CAS: 116384-56-6) is typically synthesized via a multi-step process involving the chlorination of ethylene glycol followed by the reaction with diethyl phosphate. The synthesis often requires mild to moderate conditions and can be catalyzed by phosphorus oxychloride, with yields typically ranging from 70% to 90%. The final product is a clear, colorless to slightly yellow liquid.

Diethyl [(2-chloroethoxy)methyl]phosphonate (CAS: 116384-56-6) is used in various industries, including pharmaceuticals, where it serves as a precursor for synthesizing active pharmaceutical ingredients (APIs). It is also used in the synthesis of certain polymers and as a component in sensors and as a reagent in semiconductor manufacturing processes.

When handling Diethyl [(2-chloroethoxy)methyl]phosphonate (CAS: 116384-56-6), appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats should be worn. Storage should be in a cool, well-ventilated area away from direct sunlight and heat sources. Spills should be managed using appropriate spill kits, and the material safety data sheet (MSDS) should be consulted for specific guidelines. Work should be conducted in a fume hood to minimize inhalation risk.