3-(4-Fluorophenyl)-3-oxopropanamide(CAS: 671188-82-2)

3-(4-Fluorophenyl)-3-oxopropanamide is a crystalline solid with a molecular weight of 229.19 g/mol. It has a solubility of 1.2 g/100 mL in water and is sparingly soluble in ethanol. Reactivity studies show it is moderately reactive towards nucleophiles and under acidic conditions. It exhibits good stability under normal storage conditions.

3-(4-Fluorophenyl)-3-oxopropanamide is typically synthesized via a multistep process involving the condensation of 4-fluorophenylacetic acid with acetic anhydride in the presence of a suitable catalyst such as hydroxybenzotriazole (HOBt). The reaction is highly selective and yields up to 90% of the desired product.

3-(4-Fluorophenyl)-3-oxopropanamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also has potential applications in the production of polymers and as a precursor in the development of sensors and semiconductors.

When handling 3-(4-Fluorophenyl)-3-oxopropanamide, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Ensure the use of a fume hood during handling, and store it in a cool, dry place away from direct sunlight. In case of a spill, refer to the safety data sheet (SDS) for proper cleanup procedures.