O-Tolyl acetate(CAS: 533-18-6)

O-Tolyl acetate (CAS: 533-18-6) is a colorless to pale yellow liquid with a density of approximately 0.92 g/cm³ and a molecular weight of 148.18 g/mol. It has a strong fruity odor. The compound is miscible with water and readily soluble in organic solvents such as ethanol and acetone. It is moderately reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from heat and sources of ignition.

O-Tolyl acetate (CAS: 533-18-6) can be synthesized by the acetylation of o-toluidine with acetic anhydride in the presence of a catalyst like pyridine. The reaction is typically carried out at room temperature and atmospheric pressure. The yield is usually around 85-90%. Other methods include using acetyl chloride with a Lewis acid catalyst, which provides higher selectivity and yields.

O-Tolyl acetate (CAS: 533-18-6) is used in the fragrance and flavor industry as a synthetic component of perfumes and food additives. It is also utilized in the pharmaceutical industry for the synthesis of certain drugs, and in the polymer industry as a monomer or plasticizer. Additionally, it finds applications in the production of sensors and semiconductors due to its chemical stability and reactivity.

When handling O-Tolyl acetate (CAS: 533-18-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, followed by rinsing with water. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions. Keep the substance away from heat and sources of ignition to prevent fire hazards.