Methyl 3-chloro-1H-pyrrole-2-carboxylate(CAS: 226410-00-0)

Methyl 3-chloro-1H-pyrrole-2-carboxylate (CAS: 226410-00-0) is a white to off-white crystalline solid with a molecular weight of 165.58 g/mol. It has a pKa of approximately 13.6 and is slightly soluble in water but highly soluble in organic solvents like dichloromethane and acetonitrile. This compound is reactive, particularly towards nucleophiles due to the presence of the chloro and carboxylic acid functionalities.

Methyl 3-chloro-1H-pyrrole-2-carboxylate (CAS: 226410-00-0) is commonly synthesized via the chlorination of methyl 1H-pyrrole-2-carboxylate using thionyl chloride in the presence of a base such as pyridine. The reaction is typically performed under mild conditions and yields a pure product with good selectivity and yield.

Methyl 3-chloro-1H-pyrrole-2-carboxylate (CAS: 226410-00-0) is used in the pharmaceutical industry as a precursor for the synthesis of various drug candidates. It also finds applications in the polymer industry, where it serves as a monomer or comonomer. Additionally, it is utilized in the development of sensors and semiconductors due to its electronic properties.

When handling Methyl 3-chloro-1H-pyrrole-2-carboxylate (CAS: 226410-00-0), it is crucial to use proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from incompatible materials. It should be used in a well-ventilated area or a fume hood to avoid inhalation. In case of spills, it is recommended to dispose of them according to the Material Safety Data Sheet (MSDS) guidelines.