(1R)-1-Cyclobutylethanamine(CAS: 778575-09-0)

(1R)-1-Cyclobutylethanamine is a colorless liquid with a molecular weight of approximately 88.13 g/mol. It has a pKa of about 10.0. The compound is soluble in ethanol, methanol, and dimethylformamide. It is less soluble in water. It reacts readily with strong acids and bases, and has limited reactivity under normal conditions.

(1R)-1-Cyclobutylethanamine is typically synthesized via the reaction of cyclobutylamine with (R)-2-bromopropanoic acid under basic conditions. The synthesis involves aminolysis and can be optimized with the use of a base catalyst such as potassium carbonate. The yield is generally around 75-80%, and the product can be purified by distillation.

(1R)-1-Cyclobutylethanamine finds applications in the pharmaceutical industry, particularly as a precursor in the synthesis of certain drugs. It is also used in the formulation of some polymers and as a reagent in organic synthesis. Additionally, it may have uses in the production of sensors and in semiconductor manufacturing as a dopant material.

When handling (1R)-1-Cyclobutylethanamine, wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of fumes. Store the compound in a cool, dry place away from direct sunlight and heat sources. In the event of a spill, contain the spill using an appropriate absorbent material and dispose of it according to local hazardous waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.