1,2,3,4-Tetrahydro-2-quinolinylmethanol(CAS: 40971-36-6)

1,2,3,4-Tetrahydro-2-quinolinylmethanol is a white crystalline solid at room temperature. Its molecular weight is approximately 242.31 g/mol. It has a low solubility in water (0.16 g/100 mL) but is more soluble in organic solvents like ethanol and acetone. It is moderately reactive, especially towards bases and nucleophiles, and can undergo nucleophilic substitution reactions.

1,2,3,4-Tetrahydro-2-quinolinylmethanol can be synthesized by the reduction of 2-quinolinone with a reducing agent like sodium borohydride. The reaction is typically carried out in a polar aprotic solvent like tetrahydrofuran (THF) at low temperatures. The yield is usually around 80-85%, and the product can be purified by recrystallization.

1,2,3,4-Tetrahydro-2-quinolinylmethanol is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving quinoline derivatives. It also has applications in the polymer industry as a monomer or additive. Additionally, it is used in the development of chemical sensors and in the production of semiconductors.

When handling 1,2,3,4-Tetrahydro-2-quinolinylmethanol, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be cleaned up immediately using appropriate absorbent materials. It is advisable to work in a fume hood to minimize inhalation risks. Always consult the Material Safety Data Sheet (MSDS) for detailed handling and safety information.