2-Chloro-1,6-naphthyridine(CAS: 23616-33-3)

2-Chloro-1,6-naphthyridine (CAS: 23616-33-3) is a crystalline solid with a molecular weight of approximately 201.63 g/mol. It has a solubility of about 0.01 g/L in water and is sparingly soluble in common organic solvents. This compound is moderately reactive, particularly towards nucleophiles and reducing agents. It is insoluble in water but soluble in organic solvents such as ethanol and acetone.

2-Chloro-1,6-naphthyridine is typically synthesized by the condensation of 1,6-diaminonaphthalene with thionyl chloride. This reaction involves the use of thionyl chloride in glacial acetic acid as a solvent. The yield is moderate, and the product is purified by recrystallization from an appropriate solvent. This method ensures good control over the purity and crystallinity of the final product.

2-Chloro-1,6-naphthyridine (CAS: 23616-33-3) is used in the pharmaceutical industry for the synthesis of intermediates and drug candidates. It is also utilized in the sensor industry due to its specific electronic properties, making it suitable for certain types of gas sensors. Additionally, this compound plays a role in the development of certain types of materials used in semiconductor manufacturing.

When handling 2-Chloro-1,6-naphthyridine (CAS: 23616-33-3), appropriate personal protective equipment (PPE) should be used, including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, immediately clean up with appropriate absorbent material and dispose of according to local regulations. Users should refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.