2-Methyl-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid(CAS: 16948-10-0)

2-Methyl-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid is a white crystalline solid with a molecular weight of approximately 245.34 g/mol. It is poorly soluble in water but soluble in common organic solvents. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution and esterification reactions. It has a pKa of about 4.2, indicating acidity in aqueous solutions.

2-Methyl-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid is typically synthesized via a multi-step process involving the reaction of 2-methyl-2-propanol with phosgene followed by the amidation of the resulting intermediate with an appropriate amine. The reaction is carried out under anhydrous conditions to ensure high yield and selectivity. Common solvents include dichloromethane or acetonitrile.

2-Methyl-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid is primarily used in the pharmaceutical industry for the synthesis of various biologically active compounds. It is also utilized in the polymer industry as a monomer. Additionally, it has applications in the production of sensors and semiconductors.

When handling 2-Methyl-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent material, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.