(1R,2R)-2-Aminocyclopentanol hydrochloride (1:1)(CAS: 68327-11-7)

(1R,2R)-2-Aminocyclopentanol hydrochloride (CAS: 68327-11-7) is a crystalline solid with a molecular weight of approximately 174.7 g/mol. It has a pKa of about 12.2. The compound is slightly soluble in water and ethanol but insoluble in hexane. It reacts readily with bases and can form salts with various metal ions. This compound is also known for its ability to form complexes with metal ions due to its basic nature.

(1R,2R)-2-Aminocyclopentanol hydrochloride (CAS: 68327-11-7) is typically synthesized by first preparing 2-amino-1-cyclopentanol, which can be achieved through the reduction of 2-acyl-1-cyclopentanol with hydrogen in the presence of a catalyst like Raney nickel. Subsequently, this intermediate is treated with hydrochloric acid to generate the hydrochloride salt. The reaction is carried out in an acidic medium and involves high selectivity and good yield.

The (1R,2R)-2-Aminocyclopentanol hydrochloride (CAS: 68327-11-7) is primarily used in the pharmaceutical and chemical industries. It serves as a precursor for the synthesis of various organic compounds and is also employed in the development of novel drugs. Additionally, it has applications in the production of certain polymers and as a chelating agent in analytical chemistry due to its ability to form stable complexes with metal ions.

When handling (1R,2R)-2-Aminocyclopentanol hydrochloride (CAS: 68327-11-7), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats to protect against skin and eye irritation. Work should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbents, and the area should be thoroughly washed down. Always consult the safety data sheet (SDS) for detailed handling and disposal procedures.