(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate(CAS: 1000414-38-9)

(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate is a crystalline compound with a molecular weight of approximately 242.28 g/mol. It is slightly soluble in water and has good solubility in organic solvents like ethanol and acetonitrile. This compound is reactive towards nucleophiles and can undergo ester hydrolysis under basic conditions. It is also prone to oxidation due to the presence of the hydroxyl group.

(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate can be synthesized via a multi-step process starting from benzofuran derivatives. Common methods involve protection of the hydroxyl group, followed by acylation, and subsequent deprotection. The reaction typically requires a chiral auxiliary for enantioselective synthesis, leading to a yield of up to 85%. The process usually involves the use of transition metal catalysts and organic solvents.

(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate is used in the pharmaceutical industry for the synthesis of chiral intermediates and drug candidates. It is also employed in the sensor industry for the development of gas sensors due to its reactivity with certain gases. Additionally, it has potential applications in the polymer industry as a monomer for the production of functional polymers.

When handling (S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.