6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid(CAS: 800402-07-7)

6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid is a crystalline solid with a molecular weight of approximately 220.58 g/mol. It has limited water solubility and is slightly soluble in common organic solvents. The compound shows moderate reactivity, particularly towards nucleophiles and bases. It can form stable salts and complexes with various metal ions.

6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid is typically synthesized via the chlorination of 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid. This process involves the use of chlorine gas under anhydrous conditions. The reaction is conducted in the presence of a suitable base, such as potassium carbonate, to enhance the reactivity of the pyridine ring.

6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid is used in pharmaceuticals for the synthesis of various drug intermediates and APIs. It is also applied in the development of sensors and semiconductors due to its unique electronic and structural properties.

When handling 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood due to its potential volatility and reactivity. In case of spills, neutralize the spill with a suitable chemical and dispose of it according to local regulations. A Safety Data Sheet (SDS) should always be referenced for detailed handling instructions.