2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine(CAS: 627536-09-8)

2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine is a crystalline compound with a molecular weight of approximately 423.14 g/mol. It has a pKa of about 5.0 and is poorly soluble in water, but soluble in common organic solvents. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a dry, cool place to avoid hydrolysis.

2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine is typically synthesized via multistep reactions involving electrophilic aromatic substitution and condensation reactions. The synthesis involves the use of common organic solvents and catalysts. The yield is moderate, around 50-70%, and the method is selective for the desired product. Detailed procedures can be found in the literature.

2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine is used in the pharmaceutical industry for the development of potential anti-inflammatory and anticancer drugs. It is also explored in the chemical sensing sector for its ability to detect specific ions and organic molecules. Limited applications in polymers and semiconductors are also reported, but its primary focus is on pharmaceutical and sensing applications.

When handling 2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, immediately clean up the spill with appropriate absorbent materials and report it to a supervisor. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.