1-(4-amino-2-chlorophenyl)ethan-1-one(CAS: 72531-23-8)

1-(4-Amino-2-chlorophenyl)ethan-1-one (CAS: 72531-23-8) is a crystalline solid with a molecular weight of approximately 228.59 g/mol. It has a low solubility in water (solubility: 0.02 g/L at 20°C) but is more soluble in organic solvents like methanol and acetonitrile. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be protected from strong acids and bases.

1-(4-Amino-2-chlorophenyl)ethan-1-one (CAS: 72531-23-8) is synthesized via a multistep process starting from 2-chloroacetophenone and 4-aminophenol. The key steps involve the formation of an intermediate amide followed by selective chlorination and hydrolysis. This approach provides good yield and selectivity, making it a practical method for its synthesis.

1-(4-Amino-2-chlorophenyl)ethan-1-one (CAS: 72531-23-8) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It also finds applications in the production of dyes, polymers, and sensors. Its use in semiconductors is less common but may be relevant in specialized applications.

When handling 1-(4-Amino-2-chlorophenyl)ethan-1-one (CAS: 72531-23-8), comprehensive safety measures should be followed. Always wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risk. Store the compound in a cool, dry place away from strong acids and bases. In case of a spill, immediately clean up with appropriate absorbents and refer to the Safety Data Sheet (SDS) for further instructions.