5-((tert-Butoxycarbonyl)amino)pyrazine-2-carboxylic acid(CAS: 891782-63-1)

5-((tert-Butoxycarbonyl)amino)pyrazine-2-carboxylic acid is a solid at room temperature, with a molecular weight of approximately 287.29 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and DMF. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It crystallizes in orthorhombic form and is stable under normal laboratory conditions.

5-((tert-Butoxycarbonyl)amino)pyrazine-2-carboxylic acid is commonly synthesized via the condensation of 5-amino-2-pyrazinecarboxylic acid with tert-butoxycarbonyl chloride in the presence of a base like triethylamine. The reaction typically provides good yield (70-80%) and can be performed in dimethylformamide (DMF) as a solvent. The synthesis involves careful control of reaction conditions to achieve the desired regioisomer.

5-((tert-Butoxycarbonyl)amino)pyrazine-2-carboxylic acid finds applications in the pharmaceutical industry due to its potential as a precursor in drug synthesis. It is also utilized in the polymer industry for modifying polymer structures. Additionally, it has been explored in the semiconductor industry for use in organic electronic devices and sensors.

When handling 5-((tert-Butoxycarbonyl)amino)pyrazine-2-carboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation of dust. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage.