2-Amino-1-(2,4-difluorophenyl)ethanone(CAS: 643029-92-9)

2-Amino-1-(2,4-difluorophenyl)ethanone is a crystalline solid with a molecular weight of approximately 232.09 g/mol. It is soluble in water and organic solvents like ethanol and acetonitrile. Chemically, it is relatively stable but reacts with strong acids and bases. It has a high boiling point and low solubility in non-polar solvents.

2-Amino-1-(2,4-difluorophenyl)ethanone is typically synthesized via the reaction of 2,4-difluorophenylacetyl chloride with aniline. The synthesis involves the use of a phase transfer catalyst to enhance the reaction efficiency. The yield is generally around 70-80%, and the selectivity is high, with minimal by-products.

2-Amino-1-(2,4-difluorophenyl)ethanone is predominantly used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry, where it can be used as a monomer for producing various materials. Additionally, it is used in the development of sensors and as a precursor in semiconductor manufacturing.

When handling 2-Amino-1-(2,4-difluorophenyl)ethanone, it is crucial to wear personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.