3-(4-Sulfamoylphenyl)propanoic acid(CAS: 90610-69-8)

3-(4-Sulfamoylphenyl)propanoic acid is a white crystalline solid with a molecular weight of approximately 234.2 g/mol. It has a pKa of around 4.6 and is practically insoluble in water. The compound is a weak acid and shows moderate reactivity with bases. It is stable under normal conditions but should be stored in a cool, dry place to maintain its properties.

3-(4-Sulfamoylphenyl)propanoic acid is typically synthesized by the condensation of 4-sulfamoylbenzoic acid with propionyl chloride followed by reduction of the resulting amide to an acid. Commonly used catalysts include triethylamine and catalytic amounts of sodium acetate. The yield is around 75-80%.

3-(4-Sulfamoylphenyl)propanoic acid is used in the pharmaceutical industry for the synthesis of intermediates in drug development. It also finds applications in the polymer industry as a monomer for special polymers. Additionally, it is used in the production of sensors and semiconductors due to its unique chemical properties.

When handling 3-(4-Sulfamoylphenyl)propanoic acid, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat. The compound should be handled in a well-ventilated area or fume hood to avoid inhaling dust or vapors. In case of a spill, neutralize the acid with a base and dispose of the material according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal recommendations.