1-(2-Amino-3-bromo-4-methoxyphenyl)ethanone(CAS: 923289-30-9)

1-(2-Amino-3-bromo-4-methoxyphenyl)ethanone is a white crystalline solid with a molecular weight of approximately 327.04 g/mol. It has a high melting point around 175-177°C and is slightly soluble in water. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It is prone to hydrolysis under acidic conditions and may undergo photodegradation over time.

1-(2-Amino-3-bromo-4-methoxyphenyl)ethanone can be synthesized via the bromination of 4-methoxyaniline, followed by acylation with ethyl chloroformate. The reaction typically proceeds with the use of a catalyst such as triphenylphosphine or DBU, achieving yields of around 70-80%. The process is selective and efficient, providing a clean product with high purity.

1-(2-Amino-3-bromo-4-methoxyphenyl)ethanone finds applications in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the preparation of materials for sensors and semiconductors, where its unique chemical properties contribute to the development of advanced functional materials.

When handling 1-(2-Amino-3-bromo-4-methoxyphenyl)ethanone, it is essential to follow strict safety protocols. Protective equipment such as gloves, goggles, and lab coats should be worn. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up with care, using appropriate absorbent materials. In case of exposure, seek medical attention immediately. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.