3-Chloro-6-(trifluoromethyl)-2-pyridinecarboxylic acid(CAS: 760147-01-1)

3-Chloro-6-(trifluoromethyl)-2-pyridinecarboxylic acid is a crystalline solid with a molecular weight of approximately 278.04 g/mol. It has a low solubility in water (0.01 g/L at 25°C) and is soluble in organic solvents like methanol and acetonitrile. The compound is moderately reactive, especially towards nucleophiles and bases. It is a potent electrophile in organic synthesis.

3-Chloro-6-(trifluoromethyl)-2-pyridinecarboxylic acid is typically synthesized via chlorination of 6-(trifluoromethyl)-2-pyridinecarboxylic acid or through direct substitution of chlorine on the pyridine ring. The reaction can be catalyzed by Lewis acids such as aluminum chloride. The yield is generally high, and the product is isolated via crystallization from solvents.

3-Chloro-6-(trifluoromethyl)-2-pyridinecarboxylic acid is used in the pharmaceutical industry for the synthesis of drug intermediates and in the polymer industry for the development of advanced materials. It also finds application in the production of sensors and semiconductors due to its unique electronic properties.

When handling 3-Chloro-6-(trifluoromethyl)-2-pyridinecarboxylic acid, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Keep the compound away from heat and oxidizing agents. Refer to the safety data sheet (SDS) for detailed safety information.