5-[(4-Chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid(CAS: 338760-78-4)

5-[(4-Chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid is a solid with a crystalline form. It has a molecular weight of approximately 301.07 g/mol. The compound has low water solubility and is soluble in organic solvents like DMSO. It exhibits moderate reactivity, particularly towards nucleophiles. This compound is often used in organic synthesis and as a building block in pharmaceuticals and materials science.

5-[(4-Chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid is typically synthesized via sulfenylation of 1,2,3-thiadiazole-4-carboxylic acid with 4-chlorophenylthiol. This reaction is usually performed in the presence of a catalytic amount of base such as potassium carbonate or sodium hydride. The yield is generally around 80%, and the product can be isolated by recrystallization from suitable solvents.

5-[(4-Chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid finds applications in various industries. It is used in pharmaceuticals for the synthesis of drug intermediates, in materials science as a building block for polymers, and in sensors and semiconductors for its unique electronic properties. Its use in these industries highlights its versatility and importance in modern chemical research.

When handling 5-[(4-Chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood due to its potential for generating toxic fumes. In case of spillage, it should be cleaned up using appropriate methods and materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.